Having trouble with bloating and digestive discomfort or just want to make the most of the nourishment you receive from your meals? Consider this your entry into the realm of digestive enzymes and digestive enzyme supplements.
Check out all my picks to assist in minimizing bloating and receiving digestive support. We’ll dive into the 5 best digestive enzyme supplements – Physician’s CHOICE, Zenwise Health, Enzymedica Digest Gold + ATPro, HUM Flatter Me, and NewRhythm – offering detailed ingredient, benefit, and dietary suitability breakdowns.
So, if you’re seeking a broad-spectrum solution, targeted bloating relief, or a plant-based option, this guide will prepare you with the information needed to select the best digestive enzyme supplement to enhance your digestive wellness and feel your best.
I even compiled a buyer’s guide and responded to the most common questions surrounding digestive enzymes!
Digestive enzymes are proteins that help your body to break down food and absorb nutrients. Because they’re needed for healthy nutrient absorption and gut function.
For improved digestive wellness, these enzyme supplements help break down fats, proteins, and carbohydrates. See how these potent enzymes can support you in feeling better, every single day.
Disclosure:
As a Laparoscopic Surgeon, I’m always dedicated to sharing info that can help promote healthy living! Note that this post contains affiliate links to digestive enzyme supplements on Amazon.
Which is to say, when you click through a link and buy, I get a wee commission too, at no extra cost to you. These commissions assist in funding the writing of helpful articles such as this.
I only suggest products that I think, from my knowledge of digestive health and the research, might have a benefit. It’s no replacement for medical advice.
As always, check with your doctor before starting any new supplement, particularly if you have underlying health issues or take medications. I’m here first and foremost to share useful, accurate information — your health and trust are of utmost importance to me.
| Images | Medicine Name | Key Ingredients |
|---|---|---|
![]() | Physician’s CHOICE Digestive Enzymes | Prebiotic & Probiotic Blend (159mg), Digestive Support Blend (150mg), Physician’s Choice Super Enzyme Blend (85mg) |
![]() | Zenwise Health Digestive Enzymes | Bromelain, Papain (from papaya), Inulin, Apple Pectin, Ginger Root Powder, Turmeric Root Powder, Peppermint Leaf, Sea Vegetable Complex (Nori, Wakame, Bladderwrack), Fennel Seed |
![]() | Enzymedica Digest Gold + ATPro | Full-strength digestive enzyme blend, ATPro blend (ATP, Magnesium Citrate, Phytase, CoQ10) |
![]() | HUM Flatter Me Digestive Enzymes | Digestive Enzymes, Ginger, Peppermint Leaf, Fennel Seed |
![]() | NewRhythm Digestive Enzymes | Protease, Bromelain, Papain, Amylase, Lactase, Cellulase, Lipase, Probiotics, Prebiotic XOS |
Physician’s CHOICE Digestive Enzymes

For peak nutrient uptake from every meal, rely on Physician’s CHOICE Digestive Enzymes — a potent digestive enzyme supplement. It provides unbeatable digestive support for digestive enzyme deficiency by helping to break down any and all foods.
You enjoy the benefits of 16 distinct enzymes helping to digest proteins, carbs, fruits, vegetables, beans, dairy, and fats. It includes a Prebiotic & Probiotic Blend with Organic Jerusalem Artichoke root Inulin Extract, Organic Acacia Senegal Fiber, and Chicory Root Inulin Extract.
Plus, it contains Bacillus Subtilis, Bacillus Coagulans, and Bacillus Clausii. It includes a Digestive Support Blend of Organic Peppermint Leaf and Organic Ginger Root.
Our Physician’s Choice Super Enzyme Blend gives your body a powerful dose of enzymes to boost enzymatic activity. Contains Bromelain, Protease 4.5, Protease 6.0, Papain, Peptidase, Protease 3.0, Amylase, glucoamylase, Cellulase, Invertase, Beta-glucanase, Lactase, Alpha-galactosidase, Xylanase, Hemicellulase, and Lipase.
Together, these aid in peak digestion. With 60 capsules per bottle, and just one capsule prior to each meal, these powerful enzymes will last you all month long!
For best results, consume 30 minutes before the meal, or as recommended by your physician. It’s made in the US under rigorous quality control oversight.
Category
Specifications
Product Name: Physician’s CHOICE Digestive Enzymes
Dosage Form: Capsule
Key Ingredients: Prebiotic & Probiotic Blend (159mg), Digestive Support Blend (150mg), Physician’s Choice Super Enzyme Mix (85mg)
Enzyme Types: Bromelain, Protease 4.5, Protease 6.0, Papain, Peptidase, Protease 3.0, Amylase, glucoamylase, Cellulase, Invertase, Beta-glucanase, Lactase, Alpha-galactosidase, Xylanase, Hemicellulase, Lipase
Probiotics and Prebiotics: Organic Jerusalem Artichoke root Inulin Extract, Organic Acacia Senegal Fiber, Chicory Root Inulin Extract, Bacillus Subtilis, Bacillus Coagulans, Bacillus Clausii
Target Benefits: Breaks down proteins, starches, fruits, nuts, veggies, legumes, dairy & oils; promotes intestinal health
Dietary Considerations: Not specified
Manufacturing Standards: Manufactured in the USA with strict quality control standards
Recommended Usage: One capsule before a meal, preferably 30 minutes before or as directed by your healthcare professional.
Capsule Count: 60
Quality Assurance: Science-backed, reviewed by expert physicians
Intended Audience: Individuals seeking digestive support and improved gut health
It’s produced in the USA with strict quality control management.
Category | Specifications |
|---|---|
Product Name | Physician’s CHOICE Digestive Enzymes |
Dosage Form | Capsule |
Key Ingredients | Prebiotic & Probiotic Blend (159mg), Digestive Support Blend (150mg), Physician’s Choice Super Enzyme Blend (85mg) |
Enzyme Types | Bromelain, Protease 4.5, Protease 6.0, Papain, Peptidase, Protease 3.0, Amylase, glucoamylase, Cellulase, Invertase, Beta-glucanase, Lactase, Alpha-galactosidase, Xylanase, Hemicellulase, Lipase |
Probiotics and Prebiotics | Organic Jerusalem Artichoke root Inulin Extract, Organic Acacia Senegal Fiber, Chicory Root Inulin Extract, Bacillus Subtillis, Bacillus Coagulans, Bacillus Clausii |
Target Benefits | Digests proteins, carbs, fruits, veggies, beans, dairy & fats; supports gut health |
Dietary Considerations | Not specified |
Manufacturing Standards | Manufactured in the USA with strict quality control standards |
Recommended Usage | One capsule before a meal, ideally 30 minutes prior or as directed by a healthcare professional |
Capsule Count | 60 |
Quality Assurance | Science-backed, reviewed by expert physicians |
Intended Audience | Individuals seeking digestive support and improved gut health |
Zenwise Health Digestive Enzymes and Bromelain for Gut Health – Probiotic Multi Enzymes with Prebiotics and Probiotics for Women and Men for Digestive Health and Bloating Relief for Digestion – 60 CT

Next, grab Zenwise Health Digestive Enzymes for a gut-healthy kick. You’re getting a 3-in-1 formula that combines digestive enzymes, probiotics, and prebiotics. It’s like sending an all-star roster to your digestive system.
To obtain rapid relief, the fast-acting enzymes like bromelain and papain is like the ideal option. These enzymes work quickly to help soothe digestive discomfort.
These potent, clinically-proven probiotics promote balance and harmony in your digestive tract. For focused gas and bloating relief, the Enzymes with Bromelain, Papaya & More formula is a savvy option.
These vegetarian-friendly plant-based digestive enzymes and prebiotic digestive support. This potent formula includes a cutting-edge enzyme and prebiotic system, papaya fruit powder, apple pectin, and ginger root powder.
It supports digestive health and keeps you regular. More significantly, it promotes your body’s capacity to assimilate nutrients and digest them efficiently.
It’s a vegetarian formulation that supports digestive health and immunity. Just as a reminder, this is for adults only, and you’ll want to keep it away from kids.
Consume 1 capsule with water prior to each meal. This is in order for the ingredients to be released straight where necessary — in your digestive system.
| Category | Specifications |
|---|---|
| Product Name | Zenwise Health Digestive Enzymes for Gut Health & Bloating Relief – Multi Enzymes with Probiotics & Prebiotics (60 ct) |
| Dosage Form | Capsule (vegetarian) |
| Key Ingredients | Bromelain, Papain (from papaya), Inulin, Apple Pectin, Ginger Root Powder, Turmeric Root Powder, Peppermint Leaf, Sea Vegetable Complex (Nori, Wakame, Bladderwrack), Fennel Seed |
| Enzyme Types | Digestive enzymes: Glucoamylase, Amylase, Bromelain, Cellulase, Invertase, Lactase, Bacterial Protease, Papain, Lipase, Maltase (from Aspergillus niger) |
| Probiotics and Prebiotics | Probiotic blend: Bacillus subtilis DE111, Lactobacillus acidophilus, Bifidobacterium longum, B. animalis lactis, B. bifidum, L. casei, L. rhamnosus, L. plantarum, L. salivarius, B. breve. Prebiotic: Inulin |
| Target Benefits | Supports digestive health, gut health, indigestion relief, nutrient absorption, immune support; helps relieve gas & bloating and promotes regularity |
| Dietary Considerations | Vegan-friendly, AVA-Certified Vegetarian, Non-GMO; contains sulfites |
| Manufacturing Standards | AVA-Certified Vegetarian; shelf-stable probiotics guaranteed to arrive alive in the small intestine |
| Recommended Usage | Take 1 capsule before each meal with a full glass of water (do not chew or break) |
| Capsule Count | 60 capsules per bottle |
| Quality Assurance | Contains clinically proven, shelf-stable probiotic DE111; plant-based enzymes; reputable brand listing on Amazon |
| Intended Audience | Adults (both women and men) seeking digestive support and relief from occasional bloating or gas |
Enzymedica Digest Gold + ATPro, Maximum Strength Digestive Enzymes, 45 Count

Get ready to feel the difference with Enzymedica Digest Gold + ATPro! It’s your maximum strength, daily digestive superhero for even the greasiest of banquets. This potent pancreatic enzyme formula will work to relieve symptoms of digestive enzyme deficiency.
Discover for yourself how you can experience instant relief from bloat and digestive discomfort. Our most powerful formula ever, Digest Gold + ATPro, combines a potent digestive enzyme blend with our exclusive ATPro blend, which protects enzymes for optimal activity.
It has ATP, Magnesium Citrate, Phytase and CoQ10. Each capsule packs a punch strong enough to handle more than 34 grams of fat. It breaks down 16 grams of protein and 86 grams of carbs.
That’s some serious digestive firepower. With our unique Thera-blend enzymes, you’ll experience optimal enzyme activity throughout your digestive tract — an ideal solution for individuals with digestive issues.
Be confident in what you consume. Gluten, milk, casein, soy, egg, artificial colours, flavours and GMO free. It’s vegan, Kosher and Clean Label Project Certified.
The ATPro blend provides an added lift, spurring your entire digestive system. Remember this product is not proven to diagnose, treat, cure, or prevent any disease.
Do be wary of side effects should the enzyme strength be too potent for your needs. You’ll probably have abdominal pain, nausea, migraine, gas, and bloating if you have enzyme insufficiencies.
Category
Specifications
Product Name: Enzymedica Digest Gold + ATPro, Maximum Strength Digestive Enzymes
Dosage Form: Capsule
Key Ingredients: full-strength digestive enzyme blend, ATPro blend (ATP, Magnesium Citrate, Phytase, CoQ10)
Enzyme Types: Thera-blend enzymes
Probiotics and Prebiotics: Not specified
Target Benefits: Digests large meals quickly, gives you immediate relief from bloating, promotes optimal digestive health, and gives you energy.
Dietary Considerations: Gluten, milk, casein, soy, egg, artificial colors and flavors, GMO, vegan, Kosher, Clean Label Project Certified
Manufacturing Standards: Not specified
Recommended Usage: Not specified
Capsule Count: 45
Quality Assurance: Clean Label Project Certified
Intended Audience: Individuals seeking digestive support and relief from bloating
Category | Specifications |
|---|---|
Product Name | Enzymedica Digest Gold + ATPro, Maximum Strength Digestive Enzymes |
Dosage Form | Capsule |
Key Ingredients | Full-strength digestive enzyme blend, ATPro blend (ATP, Magnesium Citrate, Phytase, CoQ10) |
Enzyme Types | Thera-blend enzymes |
Probiotics and Prebiotics | Not specified |
Target Benefits | Breaks down large meals faster, provides instant bloating relief, supports maximum digestive health, provides energy |
Dietary Considerations | Gluten-free, milk-free, casein-free, soy-free, egg-free, free from artificial colors and flavors, GMO-free, vegan, Kosher, Clean Label Project Certified |
Manufacturing Standards | Not specified |
Recommended Usage | Not specified |
Capsule Count | 45 |
Quality Assurance | Clean Label Project Certified |
Intended Audience | Individuals seeking digestive support and relief from bloating |
HUM Flatter Me Supplement

Come on, you want to be in shape inside and out! HUM Flatter Me will do exactly that. It’s packed with 18 full-spectrum digestive enzymes in a unique blend, as well as ginger, peppermint leaf, and fennel seed.
All together, these ingredients help encourage relief from bloat and healthy digestion. For best results, take 1 capsule 2 x daily before meals. That can make all the difference in how you feel after a meal!
Clinical tests revealed relief in 80% of users. Amazing, some felt up to 2 inches less bloated after just 1 use! Now THAT’s bragging rights!
I love that it pairs well with other HUM products targeting digestive health. What’s even better is knowing you can mix and match to customize the perfect combination for your specific needs.
For example, pair it with HUM’s Gut Instinct probiotic for outstanding digestive support. It’s like having your own personal support squad for your tummy!
Here is the product specification:
Category
Specifications
Product Name: HUM Flatter Me Supplement
Dosage Form: Capsule
Key Ingredients: Digestive Enzymes, Ginger, Peppermint Leaf, Fennel Seed
Enzyme Types: 18 Full-Spectrum Digestive Enzymes
Probiotics and Prebiotics: Not specified
Target Benefits: Bloating Relief, Digestion Support
Dietary Considerations: Not specified
Manufacturing Standards: Not specified
Recommended Usage: 1 capsule twice daily before meals
Capsule Count: Not specified
Quality Assurance: Clinically tested
Intended Audience: Adults seeking bloating relief and digestive support
Here is the product specification:
Category | Specifications |
|---|---|
Product Name | HUM Flatter Me Supplement |
Dosage Form | Capsule |
Key Ingredients | Digestive Enzymes, Ginger, Peppermint Leaf, Fennel Seed |
Enzyme Types | 18 Full-Spectrum Digestive Enzymes |
Probiotics and Prebiotics | Not specified |
Target Benefits | Bloating Relief, Digestion Support |
Dietary Considerations | Not specified |
Manufacturing Standards | Not specified |
Recommended Usage | 1 capsule twice daily before meals |
Capsule Count | Not specified |
Quality Assurance | Clinically tested |
Intended Audience | Adults seeking bloating relief and digestive support |
NewRhythm Digestive Enzymes 245 mg, with Probiotics and Prebiotics, Plant Based, 7 Key Enzymes, Digestion, Nutrient Absorption, Protease Amylase & Lipase, 60 Vegan Capsules

NewRhythm Digestive Enzymes are your plant-based digestive health ally. These are manufactured here in the US, in a GMP Certified Facility in New York. The formula includes seven potent enzymes to help make sure you’re digesting proteins, carbs and fats effectively and efficiently.
For instance, you’ll get protease, bromelain, and papain, all of which have been shown to digest proteins. Amylase digests carbs, and lactase enzyme digests lactose. Cellulase digests fibrous cellulose, and lipase digests fat.
Sprinkle in probiotics and prebiotic XOS for extra digestive support, and giving your gut what it craves has never been simpler! These enzymes assist in the digestion of normally hard-to-digest foods. They’re crucial to maintaining gut flora equilibrium.
These capsules contain all-natural ingredients. They’re non-GMO and gluten-free. Best of all, they’re vegan and dairy-free — a perfect nutritional addition to an array of lifestyles and diets.
With these vegan enzymes, you can take them immediately before, during, or after your meals. They’re especially helpful if you suffer from food sensitivities or intolerance. They’re delicious, even better if you’re on a high-protein diet.
It’s even more effective when taken with other probiotics.Category
Specifications
Product Name: NewRhythm Digestive Enzymes
Dosage Form: Vegan Capsules
Key Ingredients: Protease, Bromelain, Papain, Amylase, Lactase, Cellulase, Lipase, Probiotics, Prebiotic XOS
Enzyme Types: Protease, Amylase, Lipase, Lactase, Cellulase, Bromelain, Papain
Probiotics and Prebiotics: Include Probiotics and Prebiotic XOS for GI support
Target Benefits: Aids digestion, nutrient absorption, and gut health; aids in digesting tough foods; preserves flora in the intestines
Dietary Considerations: Plant-Based, Non-GMO, Gluten-Free, Vegan-Friendly, Dairy-Free
Manufacturing Standards: Manufactured in a G.M.P. Certified Facility in New York, USA
Recommended Usage: Take before, during, or after meals
Capsule Count: 60 Vegan Capsules
Quality Assurance: Formulated with 100% natural ingredients
Intended Audience: Individuals with food sensitivities/intolerances, those following high-protein diets
You can even take them in combination with other probiotics to enhance their effectiveness.
Category | Specifications |
|---|---|
Product Name | NewRhythm Digestive Enzymes |
Dosage Form | Vegan Capsules |
Key Ingredients | Protease, Bromelain, Papain, Amylase, Lactase, Cellulase, Lipase, Probiotics, Prebiotic XOS |
Enzyme Types | Protease, Amylase, Lipase, Lactase, Cellulase, Bromelain, Papain |
Probiotics and Prebiotics | Includes Probiotics and Prebiotic XOS for GI support |
Target Benefits | Supports digestion, nutrient absorption, and gut health; helps break down hard-to-digest foods; maintains gut flora balance |
Dietary Considerations | Plant-Based, Non-GMO, Gluten-Free, Vegan-Friendly, Dairy-Free |
Manufacturing Standards | Made in a GMP Certified Facility in New York, USA |
Recommended Usage | Take before, during, or after meals |
Capsule Count | 60 Vegan Capsules |
Quality Assurance | Formulated with 100% natural ingredients |
Intended Audience | Individuals with food sensitivities/intolerances, those following high-protein diets |
Buyer’s Guide
Picking the best digestive enzyme doesn’t have to be a gauntlet-style race! As someone who’s years testing out wellness options in medical settings, I’ve learned that knowing your body is half the battle.
To find the digestive enzyme that works for you, begin by evaluating your diet. Do you have difficulty digesting fats, proteins, or carbohydrates? Some, such as Physician’s CHOICE Digestive Enzymes, provide a wide spectrum to address all of these.
Others, such as Zenwise Health Digestive Enzymes and Bromelain, include ingredients that aim to promote overall gut health by incorporating prebiotics and probiotics. Don’t overlook your sensitivities.
NewRhythm Digestive Enzymes are plant-based and vegan, great if you’re avoiding animal products. If you’re seeking maximum strength, Enzymedica Digest Gold + ATPro could be king.
Allow me some anecdotal evidence. I had just recommended the HUM Flatter Me Supplement to a 24/7 bloated friend. It was this special mix that really made her feel better after she ate.
Your gut is personal. Listen to your body and really have a conversation with your doctor to determine what’s right for you.
When you select the optimal digestive enzyme, you’re able to enjoy mealtime with more ease and comfort.
Conclusion
Now that you’re a digestive enzyme guru, we hope you’ll give these little warriors a whirl! Use this guide to help you pick the best one for your tummy. Both have their benefits.
The Physician’s CHOICE gives you the full spectrum. Zenwise Health remains a powerhouse with their introduction of probiotics. For potent power, grab Enzymedica Digest Gold. HUM Flatter Me is magic for bloating. With NewRhythm, you receive a 100% plant-based replacement.
Be mindful of what feels good and what doesn’t, listen to your body. Think about what you’re in search of. Select the enzymes that best suit your lifestyle.
A healthy gut is one spoonful away! Ready to feel good now? Find out which one of these digestive enzymes you want to try first! You’ll be amazed at the digestive peace of mind it brings.
Key Takeaways
Here’s what to remember when shopping for a pancreatic enzyme supplement to help digestion and support your gut.
- Diversity is the important. Look for digestive enzyme supplements that contain a strong blend of enzymes. Pick a formula with amylase, protease and lipase to ensure they get completely broken down into sugars, amino acids, and fatty acids. This establishes a multi-pronged attack on digestive support.
- Remember the co-benefits. As with most digestive enzyme supplements, many contain a mixture of prebiotics and probiotics. These can enhance gut health by contributing to a healthy gut microbiome.
- If you’re after some deep digestion, seek out a high-potency digestive enzyme blend. These are typically formulated with a dose of enzymes for more potent assistance.
- If you’re on a special diet, like a vegan diet, make sure your digestive enzyme supplement is plant-based. That way, you can ensure it syncs with your diet.
- Read the ingredient list. Before you purchase any digestive enzyme supplement, read the label and be wary. Check a product’s ingredients, dosage instructions and any allergens or warnings they include.
- Remember, what helps one tummy may not help another. What works for one person might not even affect another. It can be a little trial and error to find the perfect digestive enzyme supplement for you.
Frequently Asked Questions
What are digestive enzymes, and why are they important?
Digestive enzymes are proteins that support the breaking down of food into smaller molecules that your body can easily absorb. They’re an integral component of good digestion that aids in optimizing the nutrients of your meals to leave you feeling vibrant and energized.
Which digestive enzyme supplement is best for bloating relief?
HUM Flatter Me, a clinically tested formula with a patent-pending 8-enzyme blend, provides digestive enzyme supplementation, with 80% of users experiencing relief from discomfort.
Zenwise Health Digestive Enzymes and Bromelain support digestion by fighting gas and bloating.
Can I take digestive enzymes if I have food sensitivities?
Definitely, NewRhythm Digestive Enzymes are great for anyone with a digestive enzyme deficiency. They contain pancreatic enzymes that assist in digesting tough foods and maintain gut flora balance.
What is the best time to take digestive enzymes?
It truly is up to the digestive enzyme products you select! For optimal benefits of pancreatic enzyme supplementation, Physician’s CHOICE advises 1 capsule should be taken 30 minutes prior to a meal.
NewRhythm works before, during, or after meals, whereas HUM Flatter Me recommends beginning with a single capsule, two times daily, prior to meals.
Are there any side effects associated with taking digestive enzymes?
Digestive enzymes could potentially cause side effects such as abdominal pain, nausea, headache, flatulence, and bloating, as reported for Enzymedica Digest Gold.
These side effects generally occur when the potency is too high.
Do digestive enzyme supplements contain probiotics?
Some do! While Physician’s CHOICE and NewRhythm have digestive enzyme products and probiotics to encourage gut health, Zenwise Health provides a 3-in-1 formula with pancreatic enzymes, probiotics, and prebiotics.
Are all digestive enzyme supplements vegetarian or vegan-friendly?
Not all, but most digestive enzyme products are! Zenwise Health and NewRhythm are plant-based and vegan/vegetarian friendly.
Enzymedica Digest Gold is a great vegan and kosher-friendly pancreatic enzyme supplement for those who have multiple dietary restrictions. Just check the label to be certain.





















